Psycho-Babble Medication Thread 388872

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celexa + nortriptyline (dosage/interaction)

Posted by yeltom on September 9, 2004, at 18:09:03

I recently added nortriptyline to 40 mg of celexa to help with IBS and to boost norepinephrine etc. I figured my target dose of the nt would be 25 mg, but I can hardly handle 10 mg. It makes me very sleepy, and when I try to up the dose I get a headache. It seems to be working well at 10 mg, but I'm so sleepy, and I've been taking it for a month. I almost want to try 5 mg, but that's such a pain because it only comes in capsules. Has anyone ever come across tablets. Does 5 or 10 mg seem like a ridicuously low dose? I know about the enzyme inhibition, but it still seems really low. Does nortriptyline increase blood levels of celexa (as well as vice versa)? Perhaps I should reduce celexa before I go down on nortriptyline? Would love to hear about anyone's experiences.

 

Re: celexa + nortriptyline (dosage/interaction) yeltom

Posted by Sad Panda on September 9, 2004, at 23:21:15

In reply to celexa + nortriptyline (dosage/interaction), posted by yeltom on September 9, 2004, at 18:09:03

> I recently added nortriptyline to 40 mg of celexa to help with IBS and to boost norepinephrine etc. I figured my target dose of the nt would be 25 mg, but I can hardly handle 10 mg. It makes me very sleepy, and when I try to up the dose I get a headache. It seems to be working well at 10 mg, but I'm so sleepy, and I've been taking it for a month. I almost want to try 5 mg, but that's such a pain because it only comes in capsules. Has anyone ever come across tablets. Does 5 or 10 mg seem like a ridicuously low dose? I know about the enzyme inhibition, but it still seems really low. Does nortriptyline increase blood levels of celexa (as well as vice versa)? Perhaps I should reduce celexa before I go down on nortriptyline? Would love to hear about anyone's experiences.
>
>
>

Hi,

I recently started taking Nort for the same reason, Celexa & Nortriptyline don't interact AFAIK, the drugs to avoid are Prozac & Paxil. The enzyme that metabolises Nortriptyline is 2D6 & this is the one that has that varies the most from person to person. It would be very worth while for you to get a plasma level taken to see how well you metabolise it.

Cheers,
Paul.

 

Re: celexa + nortriptyline (dosage/interaction) Sad Panda

Posted by yeltom on September 10, 2004, at 0:26:22

In reply to Re: celexa + nortriptyline (dosage/interaction) yeltom, posted by Sad Panda on September 9, 2004, at 23:21:15

I believe they do interact, but the enzyme inhibition is less with celexa than with prozac and paxil. Just out of curiosity, what exactly are you taking, and how much? And how has it worked for you? Thanks

> > I recently added nortriptyline to 40 mg of celexa to help with IBS and to boost norepinephrine etc. I figured my target dose of the nt would be 25 mg, but I can hardly handle 10 mg. It makes me very sleepy, and when I try to up the dose I get a headache. It seems to be working well at 10 mg, but I'm so sleepy, and I've been taking it for a month. I almost want to try 5 mg, but that's such a pain because it only comes in capsules. Has anyone ever come across tablets. Does 5 or 10 mg seem like a ridicuously low dose? I know about the enzyme inhibition, but it still seems really low. Does nortriptyline increase blood levels of celexa (as well as vice versa)? Perhaps I should reduce celexa before I go down on nortriptyline? Would love to hear about anyone's experiences.
> >
> >
> >
>
> Hi,
>
> I recently started taking Nort for the same reason, Celexa & Nortriptyline don't interact AFAIK, the drugs to avoid are Prozac & Paxil. The enzyme that metabolises Nortriptyline is 2D6 & this is the one that has that varies the most from person to person. It would be very worth while for you to get a plasma level taken to see how well you metabolise it.
>
> Cheers,
> Paul.
>

 

Re: celexa + nortriptyline (dosage/interaction) yeltom

Posted by Sad Panda on September 10, 2004, at 1:21:09

In reply to Re: celexa + nortriptyline (dosage/interaction) Sad Panda, posted by yeltom on September 10, 2004, at 0:26:22

At the moment I am blending Amitriptyline & Nortriptyline to help me get off Effexor. Last night I took 100mg of each + 75mg of Effexor. The TCA's have slowed my bowels down to one trip to the toilet per day, stoped anxiety from driving me to the toilet & also lowered my stomach acid levels.

Cheers,
Paul.


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