Psycho-Babble Medication Thread 340452

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chemist, references... on xanax's anti-d effects.?

Posted by jlbl2l on April 27, 2004, at 1:02:07

chemist,

can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant because of your thoughts on its 5ht and probably d2 activating/binding? I've researched on the net, newsgroups etc , and the closest thing i could find is a small article noting its effects (but only concerning anxiety/panic) on norep. and sero. ->

http://www3.interscience.wiley.com/cgi-bin/abstract/66004550/ABSTRACT

It also mentions some other "intriguing" benzos that I have not heard of. comments?

all the best :-)
jlbl2l
P.S. - Working On that email to you...

 

Re: chemist, references... on xanax's anti-d effects.? Ľ jlbl2l

Posted by chemist on April 27, 2004, at 1:21:07

In reply to chemist, references... on xanax's anti-d effects.?, posted by jlbl2l on April 27, 2004, at 1:02:07

> chemist,
>
> can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant because of your thoughts on its 5ht and probably d2 activating/binding? I've researched on the net, newsgroups etc , and the closest thing i could find is a small article noting its effects (but only concerning anxiety/panic) on norep. and sero. ->
>
> http://www3.interscience.wiley.com/cgi-bin/abstract/66004550/ABSTRACT
>
> It also mentions some other "intriguing" benzos that I have not heard of. comments?
>
> all the best :-)
> jlbl2l
> P.S. - Working On that email to you...

rickels and rynn, j. clin. psy. 2002; neuropharmacology 43:1269-1279, 2002;
am. fam. physician 66:1239-1248, 2002;
behav. pharmacol. 3:229-237, 1992;
psychopharmacology (berlin) 148:146-152, 2000;
...and the list goes on and on......all the best, chemist


 

Re: chemist, references... on xanax's anti-d effects.?

Posted by SLS on April 27, 2004, at 6:13:33

In reply to chemist, references... on xanax's anti-d effects.?, posted by jlbl2l on April 27, 2004, at 1:02:07

> can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant


I haven't really studied the proposed mechanisms by which Xanax (alprazolam) exerts its antidepressant effects, but it definitely does, how ever mild these effects may be. Even more intriguing is a drug called adinazolam (Deracyn). Both Xanax and adinazolam belong to the subfamily of benzodiazepines known as triazalobenzodiazepines. Adinazolam is an antidepressant devoid of hypnotic and sedative properties. It can be quite energizing. I guess these two triazalo's have some pharmacodynamic properties in common. The other triazolo currently available is triazolam (Halcion), which is the most potent of the benzodiazepines. It has not demonstrated any antidepressant effects that I know of.


- Scott


 

Re: chemist, references... on xanax's anti-d effects.? Ľ SLS

Posted by chemist on April 27, 2004, at 16:37:42

In reply to Re: chemist, references... on xanax's anti-d effects.?, posted by SLS on April 27, 2004, at 6:13:33

> > can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant
>
>
> I haven't really studied the proposed mechanisms by which Xanax (alprazolam) exerts its antidepressant effects, but it definitely does, how ever mild these effects may be. Even more intriguing is a drug called adinazolam (Deracyn). Both Xanax and adinazolam belong to the subfamily of benzodiazepines known as triazalobenzodiazepines. Adinazolam is an antidepressant devoid of hypnotic and sedative properties. It can be quite energizing. I guess these two triazalo's have some pharmacodynamic properties in common. The other triazolo currently available is triazolam (Halcion), which is the most potent of the benzodiazepines. It has not demonstrated any antidepressant effects that I know of.
>
>
> - Scott
>
>
>
>
>
hi there, from chemist....the other triazolobenzodiazepene (in addition to the 3 named above) is estazolam....as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise. i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist

 

Re: chemist, references... on xanax's anti-d effects.?

Posted by SLS on April 27, 2004, at 17:50:24

In reply to Re: chemist, references... on xanax's anti-d effects.? Ľ SLS, posted by chemist on April 27, 2004, at 16:37:42


> ..as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise.

That was not my experience with this drug. I was treated with adinazolam in 1985. Unfortunately, I donít remember the dosages used, so I canít comment on the drugís behavior throughout its clinical range. With respect to sedative and hypnotic effects, it didnít affect me in the slightest. It was incredible. The drug was remarkably clean. That isnít to say that it doesnít possess anxiolytic properties. It probably does. On this, I canít comment either since I did not suffer from anxiety at the time.

> i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist

Sure. Iíd love to see some more stuff about adinazolam. It is a very interesting drug that should probably have been pursued further.


- Scott

 

Re: chemist, references... on xanax's anti-d effects.? Ľ SLS

Posted by chemist on April 27, 2004, at 23:05:06

In reply to Re: chemist, references... on xanax's anti-d effects.?, posted by SLS on April 27, 2004, at 17:50:24

>
> > ..as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise.
>
> That was not my experience with this drug. I was treated with adinazolam in 1985. Unfortunately, I donít remember the dosages used, so I canít comment on the drugís behavior throughout its clinical range. With respect to sedative and hypnotic effects, it didnít affect me in the slightest. It was incredible. The drug was remarkably clean. That isnít to say that it doesnít possess anxiolytic properties. It probably does. On this, I canít comment either since I did not suffer from anxiety at the time.
>
> > i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist
>
> Sure. Iíd love to see some more stuff about adinazolam. It is a very interesting drug that should probably have been pursued further.
>
>
> - Scott
>
hi scott, sounds like you were in the early days of trials after upjohn released....my info comes (mostly) from www.pubmed.org on this one, single keyword adinazolam, and you can peruse abstracts that support your claims as well as those that supprt mine...all the best, chemist


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