Psycho-Babble Medication Thread 292067

Shown: posts 1 to 11 of 11. This is the beginning of the thread.

 

MAO results with adderall and effexor

Posted by slushpuppi on December 21, 2003, at 6:13:16

My pdoc told me that taking effexor and adderall will result in an MAO like drug...which was helpful to me except for the 40lb weight gain and inability to sleep after several months. Anyone feedback would be appreciated.

 

Re: MAO results with adderall and effexor

Posted by linkadge on December 22, 2003, at 8:58:57

In reply to MAO results with adderall and effexor, posted by slushpuppi on December 21, 2003, at 6:13:16

His reasoning is that the combination will provide increases in norepinephrine, serotonin and dopamine, like MAOI inhibitors.

THe theory is sound and it is worth a try.


Linkadge

 

Re: MAO results with adderall and effexor

Posted by jaby on December 22, 2003, at 12:28:30

In reply to MAO results with adderall and effexor, posted by slushpuppi on December 21, 2003, at 6:13:16

My doctor recommended something similar to me. I have yet to try it, but as previously mentioned it sounds good in theory.

 

Re: MAO results with adderall and effexor

Posted by brussell on December 22, 2003, at 16:47:08

In reply to Re: MAO results with adderall and effexor, posted by jaby on December 22, 2003, at 12:28:30

The drugs you will be taking work completely differently from MAOIs. The fact that they affect similar neurotransmitters does not mean that you will get a MAOI effect.

I'm not saying this combo wouldn't work for you; you should definitely try it. Just don't assume that you have "tried MAOIs" if it doesn't work. A MAOI might still be what you need.

No offense to anyone intended, but depression is so poorly understood that theory is at best a very vague guide. At the end of the day, you still just have to keep trying different meds until you find one or more that works.

Good luck.

 

Re: MAO results w/ adderall effexor

Posted by wsj on December 22, 2003, at 19:38:11

In reply to MAO results with adderall and effexor, posted by slushpuppi on December 21, 2003, at 6:13:16

i took effexor and augmented w/ dexedrine for about 3 years. i now take parnate (42 days)!
my experience so far is that parnate works as well to relieve my depression as the old combo w/o near the s/e. i think your pdoc is overstating when he says MAO results.

good luck,
wsj

 

MAO vs Adderall w/ Effexor

Posted by paulk on December 24, 2003, at 17:29:50

In reply to Re: MAO results with adderall and effexor, posted by jaby on December 22, 2003, at 12:28:30

I've done both - there is a big difference in how they work. Effexor is a reuptake inhibitor - so the background level of NE and SE go up - but every where. With the MAOI it only goes up where your brain is using it.

My hunch, reading between the lines, is your doc is afraid of MAOIs (in which case you need to find one with a back bone) and thinks this combo is equivelent - it isn't.

One thing I do know is that MAOIs don't poop out, but effexor/stimulents can over time. I also think there are much less side effects with MAOIs (as long as you don't have problems with the diet).


 

MAOI Nardil vs Parnate

Posted by paulk on December 24, 2003, at 17:32:11

In reply to Re: MAO results w/ adderall effexor, posted by wsj on December 22, 2003, at 19:38:11

Sounds like you have some MAOI experiance - (If you have tried both) how would you contrast Parnate vs Nardil?

 

Re: MAO vs Adderall w/ Effexor

Posted by SLS on December 26, 2003, at 20:49:28

In reply to MAO vs Adderall w/ Effexor, posted by paulk on December 24, 2003, at 17:29:50

Hi.

> One thing I do know is that MAOIs don't poop out,

I wish that were true. It is a dream of mine.


- Scott

 

Re: MAO vs Adderall w/ Effexor

Posted by kellym on December 26, 2003, at 21:00:41

In reply to MAO vs Adderall w/ Effexor, posted by paulk on December 24, 2003, at 17:29:50

> I've done both - there is a big difference in how they work. Effexor is a reuptake inhibitor - so the background level of NE and SE go up - but every where. With the MAOI it only goes up where your brain is using it.
>
> My hunch, reading between the lines, is your doc is afraid of MAOIs (in which case you need to find one with a back bone) and thinks this combo is equivelent - it isn't.
>
> One thing I do know is that MAOIs don't poop out, but effexor/stimulents can over time. I also think there are much less side effects with MAOIs (as long as you don't have problems with the diet).
>
>
>

No offense, but why do you think MAO inhibitors are incapable of "poopout". I've read other accounts of this happening, in addition to it happening to me. True, it was great when it was working (up to 135mg of Nardil and every dose below) but I don't see the need for insomnia and weight gain when it reaches a point of being ineffective. When someone does well on any medication for a lengthy time, great for them. But in contrast to what has been intimated on this board lately, like any medication, not everyone will respond to Nardil or Parnate to begin with- let alone have any success.

 

Re: MAO vs Adderall w/ Effexor kellym

Posted by paulk on December 26, 2003, at 23:34:46

In reply to Re: MAO vs Adderall w/ Effexor, posted by kellym on December 26, 2003, at 21:00:41

I should probably have said that they are not as prone to poop out probably because the higher levels of transmitter are only near the neurons that are firing. (as it is I'm here because Nardil appears to have quite working for me after several years).

The MAOIs are not for everyone, but for dysthemia (AKA chronic depression or atypical depression the most common form of affective disorder) I think the very old MAOIs are probably the best drug available. Having tried a number of other drugs, the only other one that helped was Effexor but it only helped for 6 8 weeks. I have gotten good help from Nardil for some years instead of weeks and I think there may have been some therapeutic (curative) help rather than just symptomatic help.

My current understanding is that using any of these meds will over the long term cause a desensitization of the receptors which can stop the beginning of vicious cycles. My problem is that the desensitization of seritonergic receptors was probably paired with other receptors that may now be under sensitive.

 

Re: MAO vs Adderall w/ Effexor

Posted by SLS on December 27, 2003, at 8:39:33

In reply to Re: MAO vs Adderall w/ Effexor, posted by kellym on December 26, 2003, at 21:00:41

> But in contrast to what has been intimated on this board lately, like any medication, not everyone will respond to Nardil or Parnate to begin with- let alone have any success.

Yup.

I suffer from some sort of bipolar depression that is unremitting. The only thing that ever got me well was a combination of Parnate 60mg + desipramine 150mg. Unfortunately, I became manic after about 6 months of euthymia (normothymia). The doctor elected to discontinue the medication, and when I later relapsed, the combination was no longer effective.

Just an observation: There are more descriptions of Nardil poop-out than there are of Parnate poop-out here on Psycho-Babble. Either there are just fewer users of Parnate or perhaps Nardil has a greater liability to stop working.


- Scott


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