Psycho-Babble Medication Thread 51378

Shown: posts 1 to 12 of 12. This is the beginning of the thread.

 

DULOXETINE???

Posted by ksvt on January 10, 2001, at 14:51:16

I just read an article about ADs which referred to the drug duloxetine, supposedly made by Eli Lilly. I can't seem to get to any of my bookmarked drug sites, or those that I can get to don't have information about this drug. I've never heard of it. Does anyone know what its trade name is, and any other info? Thanks ksvt

 

Re: DULOXETINE???

Posted by SLS on January 10, 2001, at 17:54:19

In reply to DULOXETINE???, posted by ksvt on January 10, 2001, at 14:51:16

Duloxetine is a combination norepinephrine and serotonin reuptake inhibitor (similar to Effexor in this regard). 5 years ago, it was planned that it undergo clinical trials. It then seemed to disappear. I don't know anything about what's going on with it now. It appeared to be a promising drug.

Where exactly did you here about it?


- Scott

 

Re: DULOXETINE???

Posted by stjames on January 10, 2001, at 18:41:39

In reply to Re: DULOXETINE???, posted by SLS on January 10, 2001, at 17:54:19

> Where exactly did you here about it?
>
>
> - Scott

James here.....

Google returns several pages of hits on this.

james

 

Re: DULOXETINE???

Posted by stjames on January 10, 2001, at 19:18:34

In reply to DULOXETINE???, posted by ksvt on January 10, 2001, at 14:51:16

Try http://www.lilly.com/about/investor/99report/english/products1.html , in 1999 it was in phase I trial with expected release 2001. Effect like Effexor, hopefully less side effects.

james

 

Re: DULOXETINE??? SLS

Posted by ksvt on January 11, 2001, at 9:09:53

In reply to Re: DULOXETINE???, posted by SLS on January 10, 2001, at 17:54:19

> Scott - the newest issue of Time magazine features a huge section on the future of drugs. There is an article in this section about drugs to treat mental illnesses which talks about the chemical action of SSRIs. It refers to fluvoxamine (which I took for a time) and duloxetine as "competing SSRIs" which "affect the same biochemical pathways, only with greater precision and fewer side effects." As I think I mentioned before if you try to search it on the Eli Lilly home page you (or at least I) come up blank. ksvt

> Where exactly did you here about it?
>
>
> - Scott

 

Re: DULOXETINE??? ksvt

Posted by r.anne on January 11, 2001, at 18:42:43

In reply to Re: DULOXETINE??? SLS, posted by ksvt on January 11, 2001, at 9:09:53

What is the brand name for duloxetine? Is it new? I wonder if I've had that one yet. Thanks in advance. :^)

 

Re: DULOXETINE???

Posted by SLS on January 11, 2001, at 18:59:45

In reply to Re: DULOXETINE??? ksvt, posted by r.anne on January 11, 2001, at 18:42:43

> What is the brand name for duloxetine? Is it new? I wonder if I've had that one yet. Thanks in advance. :^)

Unless you participated in a study using experimental drugs, I doubt you would have tried it.

I know a few of the psychopharm researchers at Lilly. I can try to contact them to find out more about it. It may take some time, though.


- Scott

 

Re: DULOXETINE???

Posted by stjames on January 11, 2001, at 19:38:42

In reply to Re: DULOXETINE??? ksvt, posted by r.anne on January 11, 2001, at 18:42:43

> What is the brand name for duloxetine? Is it new? I wonder if I've had that one yet. Thanks in advance. :^)

James here.....

Not out yet so no brand. See the 2nd post of mine in this thread for a url that will tell you more. Or a search engine, google returns lots of information but I found it hard to get very specific info. It is in phase II trial.

james

 

Re: DULOXETINE??? stjames

Posted by ksvt on January 11, 2001, at 20:21:47

In reply to Re: DULOXETINE???, posted by stjames on January 11, 2001, at 19:38:42

> >James - excuse my ignorance, but what is a phase II trial? ksvt
>
>
>
> james

 

Re: DULOXETINE???

Posted by stjames on January 12, 2001, at 0:21:32

In reply to Re: DULOXETINE??? stjames, posted by ksvt on January 11, 2001, at 20:21:47

> > >James - excuse my ignorance, but what is a phase II trial? ksvt


james here.....

Take a look at the link I mentioned earlier:

http://www.lilly.com/about/investor/99report/english/products1.html

 

Re: DULOXETINE???

Posted by r.anne on January 12, 2001, at 0:31:41

In reply to Re: DULOXETINE???, posted by SLS on January 11, 2001, at 18:59:45

> > What is the brand name for duloxetine? Is it new? I wonder if I've had that one yet. Thanks in advance. :^)
>
> Unless you participated in a study using experimental drugs, I doubt you would have tried it.
>
> I know a few of the psychopharm researchers at Lilly. I can try to contact them to find out more about it. It may take some time, though.
>******
sls: so it's not on the market yet? Then there is no brand name yet?r.anne
>
> - Scott

 

Re: DULOXETINE???

Posted by SLS on January 12, 2001, at 7:43:26

In reply to Re: DULOXETINE???, posted by r.anne on January 12, 2001, at 0:31:41

> > > What is the brand name for duloxetine? Is it new? I wonder if I've had that one yet. Thanks in advance. :^)

> >
> > Unless you participated in a study using experimental drugs, I doubt you would have tried it.

> >******
> sls: so it's not on the market yet? Then there is no brand name yet?r.anne

To the best of my knowledge, that is correct. There is no marketted product. According to the URL James provided, duloxetine is only now being tested on a small number of both healthy and ill individuals (phase II) to establish whether it is safe and shows enough efficacy to advance to large scale clinical trials (phase III). In the mean time, superficially similar antidepressant combinations that produce combined serotonin and norepinephrine reuptake inhibition. One can either try Effexor or combine an SSRI with desipramine or reboxetine (available in other countries). For me, I still have more faith in desipramine, a tricyclic antidepressant, than reboxetine. It is a proven product. If you believe yourself very treatment resistant, I read that Effexor and Remeron in combination is considered to be a "big-gun" combination. I would try it, except that Remeron didn't treat me very well the first time I tried it alone.

I think duloxetine is a drug to keep an eye on. I don't think it would be approved any sooner that two years from now. Perhaps someone else can comment on the length of time it takes to get a drug to market once phase III trials begin.


- Scott


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