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Re: NAC and firewall

Posted by zatar on August 20, 2011, at 12:19:30

In reply to NAC and other supplements per genetic testing, posted by zatar on August 20, 2011, at 11:17:31

Came across this from a link on another PB post regarding the use of NAC:

Note revised 12/21/08: On N-Acetyl Cysteine

"On 11/07/08 I added N-Acetyl Cysteine (NAC) to the combined firewall regimen, and I am removing it from the regimen as of 12/21/08. The case for NAC is that it is a pluripotent substance that contributes powerfully to most of the individual firewalls. For example, with respect to the Oxidative Damage to Tissues theory of aging, NAC is itself a powerful antioxidant and has a capability to increase intracellular glutathione, itself an important pluripotent antioxidant. It also has a capability to chelate heavy metals like lead, arsenic and mercury. With respect to the Immune System Deterioration theory of aging, glutathione is known to be of central importance for the normal functioning of lymphocytes and phagocytes and their capability to mount an effective immune response to any challenge. Glutathione has low bioavailability when taken as a supplement and is thought to be best induced by taking NAC. NAC has been shown to prevent cyclic decrease in numbers of CD4+ T cells in healthy people. NAC has been suggested as an adjunct therapy for AIDS patients. With respect to the Susceptibility to Cancers theory of aging NAC is known to inhibit growth and induce apoptosis in several human cancer cell lines, such as malignant fibroblasts and keratinocytes and the human signet ring cell gastric cancer cell line (SJ-89). NAC has been shown to exercise positive effects with respect to most of the other of the aging theories as well. With respect to the Programmed Genetic Changes theory of aging, NAC is known to inactivate NF-kappaB in multiple cell lines as do at least 38 other substances in the combined firewall. Since the metabolite of NAC lingers in the body and can be toxic unless neutralized, it is strongly suggested that NAC supplementation should be accompanied by three times the NAC dose amount of Vitamin C.

The reason for removing NAC from the combined firewall at least temporarily is a recent study that suggests NAC might not be as safe as was once thought to be. The study, widely reported in the press, reports "Strikingly, the NAC-treated mice developed pulmonary arterial hypertension (PAH) that mimicked the effects of chronic hypoxia." The effect is imputed to result from NAC falsely signalling that an oxygen shortage exists in the body. According to Dr. Ben Gaston, pediatrician and researcher who led the study. We found that an NAC product formed by red blood cells, know as a nitrosothiol, bypasses the normal regulation of oxygen sensing. It tells the arteries in the lung to remodel; they become narrow, increasing the blood pressure in the lungs and causing the right side of the heart to swell. It is unknown whether this effect also applies to humans at customary dosage levels, but prudence suggests removal of NAC from the firewall regimen until this issue can be clarified. I am grateful to Bart Decker for bringing this research to my attention."




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