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Re: Zinc for Depression

Posted by zatar on August 20, 2011, at 11:31:22

In reply to Re: Zinc for Depression torrid, posted by larryhoover on June 16, 2011, at 12:52:25

>If you're using sunscreen, you're not making vitamin D. And some people just don't make much vitamin D. Despite what you may read on the subject, there is no issue of toxicity if you use D3. D2 (ergocalciferol) does have toxic concerns, though.
>
> Lar

How does being heterozygous or homozygous for VDR Taq and/or Fok affect your vitamin D requirements? I've never been able to find an article that directly relates these polymorphisms to vitamin D status or daily requirements.

I'm +/+ for VDR Taq and my daughter is +/- for both VDR Taq and Fok. We both tend to run low or low normal on Vitamin D 25-hydroxy levels (without vit. D supplementation). My internist put me on high dose (50,000 units weekly) of D2, but it seems if D3 would be better. I'd really appreciate elucidation on this issue. BTW, an endocrinologist at Mayo that I consulted said he personally takes and recommends 2,000 i.u. D3 per day, but that vitamin D 25-hydroxy levels in the 30s are "normal" and not correlated with any disease.

Vitamin D2 is much less effective than vitamin D3 in humans: http://www.ncbi.nlm.nih.gov/pubmed/15531486

-Zatar



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