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Re: S. J. Wort (hypericum) and levothyroxine alan2102

Posted by Franz on October 13, 2007, at 8:16:48

In reply to Re: S. J. Wort (hypericum) and levothyroxine, posted by alan2102 on October 11, 2007, at 21:53:05

> > SJW is an agonist at PXR. Not only will this
> > enhance degradation via CYP activity, it will
> > also reduce absorption in the small intestine.
>
> Interesting. I looked up the CYP that SJW
> activates and it is CYP3A4, which as far as
> I can tell does not degrade thyroxine (though
> I might have missed something).
>
> Alan
>

Thanks. I should look further into this, but the info is hard to find and evaluate for me.

I found this:

St. John's Wort Hypericum
Half Life 26 hours
Washout 6 days None

http://www.mentalmeds.org/book_files/chap2.html#tth_sEc2.3.2

It does not mention thyroid interactions in the list taken from:
http://nccam.nih.gov/health/stjohnswort

Maybe the germans know more. Commission E?.

 

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poster:Franz thread:788437
URL: http://www.dr-bob.org/babble/alter/20070923/msgs/788910.html