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Re: S. J. Wort (hypericum) and levothyroxine alan2102

Posted by Franz on October 13, 2007, at 8:16:48

In reply to Re: S. J. Wort (hypericum) and levothyroxine, posted by alan2102 on October 11, 2007, at 21:53:05

> > SJW is an agonist at PXR. Not only will this
> > enhance degradation via CYP activity, it will
> > also reduce absorption in the small intestine.
> Interesting. I looked up the CYP that SJW
> activates and it is CYP3A4, which as far as
> I can tell does not degrade thyroxine (though
> I might have missed something).
> Alan

Thanks. I should look further into this, but the info is hard to find and evaluate for me.

I found this:

St. John's Wort Hypericum
Half Life 26 hours
Washout 6 days None

It does not mention thyroid interactions in the list taken from:

Maybe the germans know more. Commission E?.




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