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Re: S. J. Wort (hypericum) and levothyroxine

Posted by alan2102 on October 11, 2007, at 21:53:05

In reply to Re: S. J. Wort (hypericum) and levothyroxine, posted by tenman on October 11, 2007, at 17:54:20

> SJW is an agonist at PXR. Not only will this
> enhance degradation via CYP activity, it will
> also reduce absorption in the small intestine.

Interesting. I looked up the CYP that SJW
activates and it is CYP3A4, which as far as
I can tell does not degrade thyroxine (though
I might have missed something).





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