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Re: S. J. Wort (hypericum) and levothyroxine

Posted by tenman on October 11, 2007, at 17:54:20

In reply to Re: S. J. Wort (hypericum) and levothyroxine, posted by alan2102 on October 11, 2007, at 14:47:59

SJW is an agonist at PXR. Not only will this enhance degradation via CYP activity, it will also reduce absorption in the small intestine. SJW has a long half-life so taking split doses will not matter much once steady state levels have been reached.

What about SAM-e? I get a robust antidepressant effect from that. Have you tried it?




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