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Re: Lithium biochemistry (low level mechanisms) SLS

Posted by undopaminergic on January 25, 2023, at 8:26:49

In reply to Re: Lithium biochemistry (low level mechanisms) undopaminergic, posted by SLS on January 25, 2023, at 7:09:30

>
> > I've always largely (perhaps excessively) allowed the theory to guide me, and that includes research articles. For example, I was interested in vortioxetine (which I'm on right now) because I had read it acts on serotonin 5-HT3 receptors, which was interesting to me because I had never tried anything else with an effect on those receptors.
>
>
> Are you still taking vortioxetine?

Yes (I mentioned above that I'm on it right now).

> I think scientists had been focusing on the ability of vortioxetine to antagonize 5-HT7 receptors.
>

I was excited about that receptor, until I tried lurasidone, which turned out not to do much, if anything.

> However, the drug does so many different things, that it is sort of like throwing as much crap at the the serotoninergic wall (serotonergic receptors and SERT), that some of it is bound to stick.
>

Yes. The agonism at serotonin 5-HT1A is interesting too. It's my understanding that vortioxetine has a more "full" agonism than most other agents active at this receptor.

Apparently, the actions at all these receptors allows vortioxetine to work at lower levels of serotonin transporter (SERT) occupancy than other SERT inhibitors.

-undopaminergic


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poster:undopaminergic thread:1121631
URL: http://www.dr-bob.org/babble/20230117/msgs/1121642.html