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Re: Lamictal (lamotragine) dose 1 or 2 x a day? Jay2112

Posted by SLS on January 21, 2023, at 8:50:36

In reply to Lamictal (lamotragine) dose 1 or 2 x a day?, posted by Jay2112 on January 7, 2023, at 21:38:32

> I am restarting lamotragine. Just wondering:
>
> a) do I have to taper up again?

Yes. I would.

Lamotrigine is capable of producing Stevens-Johnson Syndrome (SJS), which can be fatal. As many as 10% of people starting lamotrigine will develop a rash, but only 0.04% will be due to SJS. SJS can show up with a latency of eight weeks after taking the first dose.

If lamotrigine therapy is to be restarted, even after a brief period of abstention, some guidelines mandate that you restart it as if it were your time taking it. One can restart lamotrigine, even if the first exposure precipitated a rash. In this case, it is recommended to wait eight weeks before restarting it. Not all rashes are Stevens-Johnson Syndrome. However, it can show up with a latency of eight weeks from the first dose. The dosage recommendations for treating bipolar depression is 100-400 mg/day. In my estimation, 200 mg/day is the sweet-spot that most people with bipolar depression. The recommended maximum dosage to treat seizure disorders is 500 mg/day. However, some people need as much as 700 mg/day. I need 300 mg/day. I have no side effects at this dosage. My memory and cognition seem to be unaffected now, but they did appear at the very beginning of treatment as a startup side effect.


> b) dose once or twice a day?

I would recommend twice-a-day dosing, although once-a-day is an option offered by the drug company. For bipolar depression, I think most clinicians will use a twice-a-day regimen. For me, at 300 mg/day, once a day dosing leaves me deteriorating into depression before each dose. Teva makes an extended release "Lamotrigine XR". I know nothing about its clinical dosing frequency.


> Also curious, it seemed to work well with methadone, helping with my rapid-metabolism problem. I zip through, metabolically, drugs very quick, methadone alone within anywhere from 2 to about 14 hours. (Through our estimates. He had me sit in his office after a dose, at about the 2 week mark, and my subjective estimate of effect was about 4 hours. I know...I know...much more is dependent.)

> Valproate inhibits the metabolism of lamotrigine quite a bit. I don't know at what dosage you would need to take it in order to match your metabolism. Is there any positive therapeutic effect of methadone that makes it an ideal adjunct?

> The literature doesn't mention a lot about lamotrigine use in concurrent disorders.

Which ones?


- Scott



Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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