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Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid SLS

Posted by Jay2112 on January 6, 2023, at 19:58:49

In reply to Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid Hugh, posted by SLS on January 6, 2023, at 12:53:52

> > Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.
> >
> > Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.
> >
> > Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.
> >
> > https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub
> >
> > https://www.yalemedicine.org/news/long-covid-brain-fog-treatment
>
>
> Does guanfacine produce depression as a side effect as often as clonidine does?
>
>
> - Scott

I don't think guanfacine is as strong a sedative as clonidine. I honestly did not find clonidine depressing, but just that it slows you down. I think because of the norepinephrine suppression, it also makes you achy and tired. But that is dose dependent.

Jay



Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1121495
URL: http://www.dr-bob.org/babble/20220917/msgs/1121499.html