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Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid Hugh

Posted by SLS on January 6, 2023, at 12:53:52

In reply to Guanfacine + NAC for PTSD, TBI, ADHD, long Covid, posted by Hugh on January 6, 2023, at 8:34:11

> Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.
>
> Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.
>
> Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.
>
> https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub
>
> https://www.yalemedicine.org/news/long-covid-brain-fog-treatment


Does guanfacine produce depression as a side effect as often as clonidine does?


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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