Psycho-Babble Medication | about biological treatments | Framed
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Re: SLS, anyone: taking Seroquel and propranolol

Posted by SLS on January 5, 2023, at 7:28:28

In reply to Re: SLS, anyone: taking Seroquel and propranolol, posted by undopaminergic on December 25, 2022, at 11:02:49


> > But, I am wondering about taking Seroquel XR along with propranolol. I am looking help balance my norepinephrine Seroquel has a norepinephrine agonist as a metabolite.
> >
> Quetiapine (active ingredient of Seroquel) or its metabolite norquetiapine is not an adrenergic *agonist*, but an *antagonist*. It has the highest affinity for histamine H1-receptors, and the next highest is for alpha1-adrenoceptors. This would imply that it may cause orthostatic hypotension.
> > Oh, and undopaminergic, I am doing well on vortioxetine as well, too. I hope you are still doing well, too.
> >
> I'm still enjoying occasional mood peaks from it.
> -undopaminergic

I'm happy to see that your depression is budged by your treatments. Of course, this is a good thing. It might indicate that you are treatable after all. I don't know where you guys are in your treatment, but having a short-lived "blip" improvement at the beginning sometimes prognosticates a better response weeks later. The rule of thumb is that if you experience an improvement by the end of week 4 at a therapeutic dosage, regardless of how small, another two weeks of treatment is indicated.

You might find an effective combination of drugs by taking inventory of your past treatments, and identifying which of them provided a perceptible improvement, hopefully a persistent one. You might then choose combinations of those drugs that come from different classes.

I am having success with:

Nardil - 90 mg/day
Nortriptyline - 100 mg/day
Lamotrigine - 300 mg/day
Lithium - 300 mg/day.

Each of these drugs produced a mild, but noticeable persistent improvement when added to my treatment regime. Perhaps not so surprisingly, adding low-dosage lithium (300 mg/day) produced an improvement within 6 hours of taking my first dose of 300 mg in the morning. At the time, I was taking Parnate and desipramine - and possibly lamotrigine.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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