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Re: Bipolar and constipation p.s. SLS

Posted by undopaminergic on January 4, 2023, at 4:22:28

In reply to Re: Bipolar and constipation p.s. undopaminergic, posted by SLS on January 3, 2023, at 13:07:21

> > > Interestingly, caffeine pills were not as helpful as coffee, even when I took a fraction of a pill. I think the pills contained 100 mg/day. Does that sound right?
> > >
> >
> > Yes, in fact I've never seen a caffeine pill that wasn't 100 mg of the active principle.
> >
> > > I had to meter my intake of coffee carefully. Just a small amount - 1/4 a cup - worked wonders. Anything over that left me in a state of fatigue and brain-fog that would last all day.
> > >
> >
> > I've had paradoxical sedative effects of caffeine, especially at higher doses.
> >
> > As I mentioned in another post (vortioxetine plus caffeine), I need another substance, typically a dopaminergic stimulant, in combination, to allow the caffeine to have a stimulant effect, but apparently vortoxetine can work too.
> >
> > -undopaminergic
>
>
> Did aripiprazole (Abilify) help at all?
>

No, it did not. But I don't remember trying caffeine with it.

> Abilify, like other D2 antagonists, increases That might add an increase in dopamine release, but mostly at low dosages.
>

The above looks like one sentence interrupted in the middle by another sentence. I don't dare to try and interpret it.

> This is what I remember to be guideline for:
>
> 2-5 mg/day for depression - presynaptic receptor blockade + Postsynaptic receptor blockade.
> 10-20 mg/day for bipolar mania.
> 20-30 mg/day for schizophrenia, schizoaffective disorder, psychosis.
>
>
> - Scott
>
>

I thought aripiprazole was a direct agonist-antagonist, rather than working via autoreceptors.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20220917/msgs/1121481.html