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Re: Lithium effects on hippocampal glutamate

Posted by SLS on January 2, 2023, at 12:23:43

In reply to Re: Lithium effects on hippocampal glutamate undopaminergic, posted by SLS on January 1, 2023, at 20:11:51

Hi, UD.

The dosage-response curve extant to my exposure to lithium is biphasic. I have been posting the link you provided for several years now as providing a possible biological rationale for my experience with lithium - which is the bimodal dosage-response curve for glutamate release. Again, my reaction to varying dosages of lithium is biphasic:


This is my biphasic dosage-response reaction to varying dosages of lithium in the treatment of depression:

150 mg/day = No improvement.
300 mg/day = 100 % remission.
450 mg/day = 100% relapse.


The generalization most often found in the medical literature is that:

Low glutamate = Depression.
High glutamate = Mania

I think it is prudent to use high dosages of lithium whenever there is a history of spontaneous mania or schizoaffective disorder - bipolar-type.

Given that the occurrence of side effects of lithium are dosage-dependent, the low dosages suggested by researchers for treating depression have very little, if any, liability to cause kidney or thyroid damage. I find it hard not to think that low-dosage lithium should be used routinely in treatment-resistant cases.

One caveat: It sometimes happens that the antidepressant activity of lithium is extinguished when it is discontinued and then restarted. This phenomenon was described in 1992 by Robert Post, MD at the National Institute of Mental Health (NIMH) department of the NIH. He named it "Lithium-discontinuation induced lithium-refractoriness".

https://pubmed.ncbi.nlm.nih.gov/1443252/


More citations:

https://pubmed.ncbi.nlm.nih.gov/?term=Lithium+discontinuation+induced+lithium+refractoriness&sort=date


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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