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Re: Tentative remission on ketamine

Posted by Jay2112 on January 1, 2023, at 14:49:09

In reply to Re: Tentative remission on ketamine undopaminergic, posted by SLS on December 31, 2022, at 17:28:38

> Hi, UD.
>
> > In my view, NMDA-glutamatergic receptor antagonists, like ketamine or memantine, enhance the *functional* dopaminergic tone, without necessarily elevating dopamine concentrations at all.
>
> What is "dopaminergic tone"?
>
> How does blocking NMDA receptors result in increased dopaminergic tone?
>
> Thanks.
>
> I am clueless as to what NMDA receptors are all about, other than their endogenous ligand is glutamate.
>
>
> - Scott

Don't know about tone. But, possibly the way this GABA agonist pregabalin is considered "addictive" explains the relation:

https://www.nature.com/articles/s41598-019-51556-4

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1121402
URL: http://www.dr-bob.org/babble/20220917/msgs/1121443.html