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Re: Ketamine response inadequate? - Add magnesium SLS

Posted by SLS on January 1, 2023, at 8:04:34

In reply to Ketamine response inadequate? - Add magnesium, posted by SLS on January 1, 2023, at 6:31:39

A better explanation.

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I recall reading a paper quite a few years ago that described an interaction between magnesium and the NMDA glutamate receptor. So, I played a hunch and searched for a link between magnesium, ketamine, and how they might interact together at the NMDA glutamate receptor. I was hoping to help Beckett2 and the use of ketamine I.V. I was excited, but not terribly surprised that I found one. When ketamine and magnesium are both introduced to the NMDA receptor, their actions become synergistic not additive. Their presence together at the receptor leads to a much greater degree of antagonism. Supposedly, this would enhance the antidepressant and anti-inflammatory properties of ketamine.

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"Combination of ketamine and magnesium in a normal magnesium level presents a superadditive effect in depression treatment."

From: Magnesium and ketamine in the treatment of depression

https://pubmed.ncbi.nlm.nih.gov/31488789/

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Going back to 1992, one of my research doctors at the NIH described to me his pet theory. He taught me that calcium and magnesium were essentially adversaries along the path leading up to the release of neurotransmitter. When an action potential (message) flows to the end of the first neuron, the electrical energy must be transduced into chemical energy in order to pass the message along to the next neuron. At the end of the first neuron are small channels in the cell membrane that allow calcium ions to rush in when the message arrives there. The calcium ions cause the vesicles where the neurotransmitter is stored to rush up to the presysnaptic membrane and release it into the synaptic cleft (gap). Magnesium essentially reduces the excitability of the neurons by preventing calcium from entering the calcium channels. I guess the function of magnesium is to act like a buffer and to help prevent the emergence of a runaway system.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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