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Re: Tentative remission on ketamine

Posted by SLS on December 31, 2022, at 23:07:42

In reply to Re: Tentative remission on ketamine SLS, posted by beckett2 on December 30, 2022, at 16:09:35

> Hi, Scott,
>
> Generally, my physical health is better all around. I 'think' my depression, etc, is heavily weighted toward sleep disturbance and inflammation. With more study, we might find ketamine is effective for certain types of depression and less so for others. A few years from now there will be new treatments from psychedelics and dissociative that will help a suite of MH ailments.
>
>


Ketamine is confusing to some researchers. It is thought to increase neuroplasticity acutely, but makes cells more vulnerable to hypoxic stress. Fortunately, hypoxic conditions aren't something likely to be encountered. Perhaps you have already seen the following abstract. It posits that it is neuroinflammation that is the common denominator between depression and the ability of ketamine and several other psychoactive substances to treat it.

One drug that has been used to reduce inflammation in the brain is monocycline. It is marketed as an antibiotic in the tetracycline class. My doctor has been focusing on brain inflammation for quite awhile. Monocycline reduces the secretion of pro-inflammatory cytokines from microglia. It gave me enough of an improvement to remain on it for over a year. However, a black-and-blue hyperpigmentation emerged on my feet and shins. Although benign, it looked like hell. It took perhaps two years to completely disappear. For many people, there is a residual that never disappears.

From what you've read, does depression cause inflammation or does inflammation cause depression?

My intuition suggest to me that it is the depression that starts first. Once triggered, perhaps depression places enough stress on the brain and CNS to cause an inflammatory reaction facilitated by increased microglial activity. I get the feeling that the core depressive disorder and the inflammation begin to feed off each other once both are established. I never researched the matter.

The immune system is probably the second most complicated system in the body to understand, with the brain being the first.


Abstract:

"Neuroinflammation and neuroprogression in depression: Effects of alternative drug treatments"

https://pubmed.ncbi.nlm.nih.gov/36388140/


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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