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Re: Tentative remission on ketamine undopaminergic

Posted by SLS on December 31, 2022, at 17:28:38

In reply to Re: Tentative remission on ketamine, posted by undopaminergic on December 31, 2022, at 14:03:45

Hi, UD.

> In my view, NMDA-glutamatergic receptor antagonists, like ketamine or memantine, enhance the *functional* dopaminergic tone, without necessarily elevating dopamine concentrations at all.

What is "dopaminergic tone"?

How does blocking NMDA receptors result in increased dopaminergic tone?

Thanks.

I am clueless as to what NMDA receptors are all about, other than their endogenous ligand is glutamate.


- Scott


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URL: http://www.dr-bob.org/babble/20220917/msgs/1121435.html