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Vortioxetine plus caffeine

Posted by undopaminergic on December 31, 2022, at 13:55:06

I'm on vortioxetine 5 mg/day and have been on it for about 3 weeks.

I had the opportunity to perform a little experiment.

Caffeine alone normally does nothing for me, even at high doses. Once, I took 3000 mg and got no stimulant effect. All it did was give me the worst night in my whole life, as I got extremely sick to my stomach.

Caffeine does work very well for me with a proper dopaminergic stimulant like methyl- or ethylphenidate in the background. It adds a major nootropic dimension to the dopaminergic drug. I get an almost "flight" of ideas, a cavalcade of interesting ideas. Furthermore, it has general, "normal" stimulant effects like enhancement of wakefulness.

So, I was going to see how caffeine worked with vortioxetine in the background. So, I took 500 mg, and I was pleasantly surprised! I wasn't expecting any effect at all, but I felt less apathetic, more awake, more attentive, and more energetic. I read some neuroscientific (full) articles and was comprehending them well.

Alas, I was unable to reproduce the experience the day after with the same 500 mg amount. It may be that a higher dose would have worked, but I didn't want to get into a chase for a high that takes higher and higher doses.

Has anyone else found that caffeine only works in combination with other drugs? Which ones?





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