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TCA + Effexor Combo / Maximum Effexor Dosage

Posted by SLS on December 31, 2022, at 12:48:34

Most importantly, the maximum dosage of Effexor has been determined by clinicians using the drug in their practice and investigators using clinical trials is 300 mg/day - NOT 225 mg/day. If you stop at 225 mg/day when you tolerated it well, not going to 300 mg/day is practically mal-practice in my view. Investigators have used dosages of 600 mg/day when determining the effective dosage range of Effexor - especially in severe or treatment-resistant depression.


There are some interesting reports of adding venlafaxine (Effexor) to an ongoing treatment of clomipramine (Anafranil) or imipramine (Tofranil).


Generally speaking, clomipramine is considered the most effective tricyclic antidepressant (TCA) in that it will get more people well than any of the others. Amitriptyline is often rated as 2nd and imipramine 3rd.


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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