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Re: Bipolar and constipation p.s. Jay2112

Posted by SLS on December 30, 2022, at 21:39:13

In reply to Re: Bipolar and constipation p.s. Jay2112, posted by Jay2112 on December 30, 2022, at 17:09:43

> Forgot to add:
>
> 150mg venlafaxine in am
> 75mg venlafaxine in pm
> 150mg pregabalin 3x per day
> 1mg clonazapam 3x day
> 200 carbamazepine 3x daily
> 40mg propranaolol 2 x day
> 5mg vortioxetine 1x day
>
> PRN risperidone, clonidine, methaprozine
>
> herbals, various, 1-2x per day
>

I don't have much of a feel for the dosage range for pregabalin, even though I had tried it. It made me feel pretty good during the first two days. It then turned very, very foul on me. I experienced psychic pain and terrible brain-fog. It took at least 2 weeks after stopping it to recover.

For venlafaxine, I have a better feel. In my estimation, no one should stop at 225 mg/day if they can tolerate 300 mg/day. Of course, side effects might re-emerge or get worse temporarily upon a dosage increase. You don't know until you try. I was dosing 150 mg b.i.d. There was no way that I could get away with 300 mg once a day dosing. Withdrawal would set in. Infrequently, doctors will prescribe 375 mg/day.

The one other comment I have involves clonidine. As a presynaptic NE alpha-2 agonist, clonidine reduces the manufacture and release of norepinephrine. Lots of people who never had a single episode of depression went on to become depressed when taking clonidine as an antihypertensive. My grandmother was an example of this. Fortunately, I had expected depression as being a possible reaction to clonidine, and very quickly had her discontinue it. I then made an appointment to see her original doctor. Her depression dissipated within 2-3 days.

Can you describe how vortioxetine affects you? Did you add after establishing venlafaxine?

Thanks.

This one is new to me:

https://www.medicines.org.uk/emc/product/10954/


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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URL: http://www.dr-bob.org/babble/20220917/msgs/1121422.html