Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Tolerance is just so low!! undopaminergic

Posted by SLS on December 28, 2022, at 21:20:47

In reply to Re: Tolerance is just so low!! SLS, posted by undopaminergic on December 28, 2022, at 16:40:08

You make my brain hurt.

What is your impression of zuranolone? Before I hit pay-dirt with my current drug regime, zuranolone was the drug I was most interested in. All I know about it pharmacologically is that it is described as a positive allosteric modulator of GABA-A receptors. Zuranolone works to potentiate GABA-mediated currents. I imagine you know more than me about proposed role of GABA in depression. From what I understand, zuranolone increases the reactivity of GABA-A receptors, thus potentiating GABA currents. How might the stimulation of GABA-A receptors manifest?

In clinical trials, zuranolone was reported by the manufacturer to be effective in treating Major Depressive Disorder, Bipolar Depression and Post-Partum depression. I don't know which indications(s) SAGE Pharmaceuticals will apply for.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1121100
URL: http://www.dr-bob.org/babble/20220917/msgs/1121388.html