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Re: Tolerance is just so low!! undopaminergic

Posted by SLS on December 28, 2022, at 14:18:41

In reply to Re: Tolerance is just so low!!, posted by undopaminergic on December 8, 2022, at 7:15:35

> > > maybe...a non-antidepressant approach?
> >
> > Whatever works. It would be an instructional exercise to have people list those drugs or other substances that worked best for them.
> >
>
> I won't try to go through them all, but my best combination was buprenorphine + methylphenidate. I felt I was in the process of getting on my feet again when the drugs were taken away from me.
>
> -undopaminergic


What property of buprenorphine do you think mitigated your depressive symptoms? What led you to combine the two drugs?

I found this:

"Major Depressive Disorder and Kappa Opioid Receptor Antagonists"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871611/

Buprenorphine is a partial agonist at the mu opioid receptor and an *antagonist* at the kappa receptor, which could explain the antidepressant properties of buprenorphine. Perhaps you can find another kappa receptor antagonist. I wouldn't know where to look.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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