Psycho-Babble Medication | about biological treatments | Framed
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Re: Tolerance is just so low!! undopaminergic

Posted by SLS on December 28, 2022, at 14:18:41

In reply to Re: Tolerance is just so low!!, posted by undopaminergic on December 8, 2022, at 7:15:35

> > > maybe...a non-antidepressant approach?
> >
> > Whatever works. It would be an instructional exercise to have people list those drugs or other substances that worked best for them.
> >
> I won't try to go through them all, but my best combination was buprenorphine + methylphenidate. I felt I was in the process of getting on my feet again when the drugs were taken away from me.
> -undopaminergic

What property of buprenorphine do you think mitigated your depressive symptoms? What led you to combine the two drugs?

I found this:

"Major Depressive Disorder and Kappa Opioid Receptor Antagonists"

Buprenorphine is a partial agonist at the mu opioid receptor and an *antagonist* at the kappa receptor, which could explain the antidepressant properties of buprenorphine. Perhaps you can find another kappa receptor antagonist. I wouldn't know where to look.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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