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Re: SLS, anyone: taking Seroquel and propranolol

Posted by undopaminergic on December 25, 2022, at 11:02:49

In reply to SLS, anyone: taking Seroquel and propranolol, posted by Jay2112 on December 15, 2022, at 20:15:53

> But, I am wondering about taking Seroquel XR along with propranolol. I am looking help balance my norepinephrine Seroquel has a norepinephrine agonist as a metabolite.

Quetiapine (active ingredient of Seroquel) or its metabolite norquetiapine is not an adrenergic *agonist*, but an *antagonist*. It has the highest affinity for histamine H1-receptors, and the next highest is for alpha1-adrenoceptors. This would imply that it may cause orthostatic hypotension.

> Oh, and undopaminergic, I am doing well on vortioxetine as well, too. I hope you are still doing well, too.

I'm still enjoying occasional mood peaks from it.





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