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Re: Trimipramine SLS

Posted by Jay2112 on December 17, 2022, at 17:43:22

In reply to Re: Trimipramine undopaminergic, posted by SLS on December 17, 2022, at 15:46:57

> Hi, UD.
>
> > > I would also consider trimipramine. However, I don't have a clinical "feel" for trimipramine. Do you have any opinions regarding trimipramine?
> > >
> >
> > I started trimipramine at 25 mg/day near the end of September 2019. It felt quite promising early on in treatment, and I often felt it was the best medication I've tried that is classified as an antidepressant. Now, I'm at 150 mg/day and it's been a long time, and I'm not really sure it is doing anything any more. The most promising signs came early in treatment, at very low doses. It did not get better with dose increments, but I'm not sure it got worse either.
> >
> > Pharmacodynamically, I find the most interesting action is histamine H2-receptor antagonism. Another interesting property is that it suppresses cortisol release acutely.
> >
> > It is a very strong antihistamine (H1-receptor), so it is best taken at night.
> >
> > -undopaminergic
>
>
> That's valuable information. Thanks.
>
> Trimipramine was the second drug my current doctor tried on me. The first was doxycyline. He wanted to rule-out Lyme Disease. I don't remember if I was taking any other drugs at the time. It didn't make me feel worse, which by itself is a blessing. I don't remember dosages or the length of the trial. It didn't affect me one way or the other.
>
> Do you think trimipramine helps at all by improving sleep architecture? I didn't know that it was so antihistaminergic.
>
>
> - Scott
>
>

Sorry to hijack your post, Scott. But, the sleep architecture thing is interesting. When I first started antidepressants, in the early 90's, it seemed a.d.'s worked best by suppressing my hyper-REM sleep..hyper REM being a strong indicator of depression. However, a few decades later, I started to 'crave' REM sleep. So, mirtazapine seemed to help bring it back. Plus, I lowered my Effexor dose. Effexor is, by far, the greatest REM-killer, in my experience.

I am interested, again, in trimipramine. When I first tried it, it had the antipsychotic pro-REM quality.

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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Psycho-Babble Medication | Framed

poster:Jay2112 thread:1121195
URL: http://www.dr-bob.org/babble/20220917/msgs/1121274.html