Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Trimipramine undopaminergic

Posted by SLS on December 17, 2022, at 15:46:57

In reply to Trimipramine SLS, posted by undopaminergic on December 17, 2022, at 8:22:37

Hi, UD.

> > I would also consider trimipramine. However, I don't have a clinical "feel" for trimipramine. Do you have any opinions regarding trimipramine?
> >
>
> I started trimipramine at 25 mg/day near the end of September 2019. It felt quite promising early on in treatment, and I often felt it was the best medication I've tried that is classified as an antidepressant. Now, I'm at 150 mg/day and it's been a long time, and I'm not really sure it is doing anything any more. The most promising signs came early in treatment, at very low doses. It did not get better with dose increments, but I'm not sure it got worse either.
>
> Pharmacodynamically, I find the most interesting action is histamine H2-receptor antagonism. Another interesting property is that it suppresses cortisol release acutely.
>
> It is a very strong antihistamine (H1-receptor), so it is best taken at night.
>
> -undopaminergic


That's valuable information. Thanks.

Trimipramine was the second drug my current doctor tried on me. The first was doxycyline. He wanted to rule-out Lyme Disease. I don't remember if I was taking any other drugs at the time. It didn't make me feel worse, which by itself is a blessing. I don't remember dosages or the length of the trial. It didn't affect me one way or the other.

Do you think trimipramine helps at all by improving sleep architecture? I didn't know that it was so antihistaminergic.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1121195
URL: http://www.dr-bob.org/babble/20220917/msgs/1121269.html