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Re: Finally trying vortioxetine -- initial impressions NKP

Posted by SLS on December 17, 2022, at 15:40:49

In reply to Re: Finally trying vortioxetine -- initial impressions, posted by NKP on December 17, 2022, at 6:54:48

> > > Hi UD:
> > >
> > > I too take vortioxetine, and find the nausea is very least when I take it later in the day/evening, with food. Ginger also helps. I have read the nausea may be from the cholinergic effects, which are a positive aspect of this drug. Ginger is an excellent anti-nauseant.
> > >
> >
> > Hi, Jay.
> >
> > Is that PRO-cholinergic? How does that work?
> >
> > Thanks.
> >
> >
> > - Scott
> >
> >
>
> Are there other antidepressants that are pro-cholinergic too? Might this account for the side-effect of excessive sweating that many antidepressants have?

That's a great question. I never looked into it. The first antidepressant I ever tried

No. It is anticholinergic drugs (muscarinic receptor antagonists) that produce increased sweating.


- Pro-cholinergic drugs are depressogengic (pilocarpine).

- Anti-cholinergic drugs are antidepressant (scopolamine).

Scopolamine has been studied as a rapid-acting antidepressant. I don't see much about it anymore. However. I haven't been following it.


- Scott



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I dream of things that never were and ask why not.

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