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Trimipramine SLS

Posted by undopaminergic on December 17, 2022, at 8:22:37

In reply to Re: Linkadge medication Jay2112, posted by SLS on December 5, 2022, at 22:09:16

> I would also consider trimipramine. However, I don't have a clinical "feel" for trimipramine. Do you have any opinions regarding trimipramine?

I started trimipramine at 25 mg/day near the end of September 2019. It felt quite promising early on in treatment, and I often felt it was the best medication I've tried that is classified as an antidepressant. Now, I'm at 150 mg/day and it's been a long time, and I'm not really sure it is doing anything any more. The most promising signs came early in treatment, at very low doses. It did not get better with dose increments, but I'm not sure it got worse either.

Pharmacodynamically, I find the most interesting action is histamine H2-receptor antagonism. Another interesting property is that it suppresses cortisol release acutely.

It is a very strong antihistamine (H1-receptor), so it is best taken at night.





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