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Re: Antipsychotics and brain volume

Posted by NKP on December 4, 2022, at 13:51:07

In reply to Re: Antipsychotics and brain volume, posted by Jay2112 on December 4, 2022, at 11:13:05

This is a study on brain volume change during flupentixol use:

Antipsychotic naive patients having their first schizophrenic episode were given flupentixol for one year. A control group consisting of non-schizophrenic subjects who were not given an antipsychotic, was included.

There are a few points in the study that I find curious:

(i) The schizophrenia group actually started with *higher* average grey matter volume than the control group (449 949 mm^3 vs 445 567 mm^3). I don't know if this difference is statistically significant though.

(ii) Both the schizophrenia group *and the control group* had a reduction in grey matter volume over the course of the twelve months (4.6 % vs 1.12 %). Again I don't know if the loss of grey matter volume in the control group is statistically significant.

(iii) The white matter volume of *both* groups increased: 2.5 % for the schizophrenia group, and 1.4 % for the control group.

(iv) The subcortical grey matter volume of *both* groups increased: 0.5 % for the schizophrenia group, and 1.5 % for the control group. I don't know if this increase in the schizophrenia group is statistically significant.

These figures are only averages taken across the groups. For example, the change in grey matter volume mentioned in point (ii) above, varied from around -2 % to as much as around -8 % for the schizophrenia group, and from around 0 % to around -2 % for the control group.




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