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Re: p.s. Suicide and antidepressants jay2112

Posted by linkadge on November 26, 2022, at 10:30:45

In reply to Re: p.s. Suicide and antidepressants, posted by jay2112 on November 25, 2022, at 23:57:28

I agree. Not to be too conspiratorial, but there are still major issues in the way that clinical trials are conducted, who is overseeing it, and what data is ultimately disclosed.

I trust some of the older drugs more because they were discovered serendipitously rather than through some purposeful engineered planning that has more to do with maximizing profits than trying to improve severe depression. The SSRIs were money makers not because they helped severe depression, but because they were tolerable enough to feed to the masses and provided some needed emotional anesthesia for the everyday destressed patient.

On another note ... GSK has studies showing that 10mg of paroxetine was virtually as effective as 20mg (about 98% as effective) yet the 20mg dose was ultimately perused because ... (maybe they knew it would be harder to discontinue??) and hence helping to crystalize future profits?





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