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Re: Tolerance is just so low!! SLS

Posted by jay2112 on November 22, 2022, at 21:44:03

In reply to Re: Tolerance is just so low!! jay2112, posted by SLS on November 21, 2022, at 21:10:14

> > I am sure your mechanisms are right, Scott...but the bottom line, clonidine is a very powerful drug, given 0.1mg's lower almost anyone's blood pressure. Clonidine was used quite a bit in the 70's and 80's to help many rock stars and celebrities kick heroin. I have had that experience of sub-low blood pressure, and it is not a nice feeling.
> >
> > So, I think, tiny amounts are the key. I don't think, for psychiatric use, there is any need to go above 0.1mg b.i.d. Your body does adjust, once on a regular schedule. It was *magic* for my PTSD nightmares. But, I tried raising the dose. Not good for mental health.
> >
> > Jay
>
> If you take a look in the literature, depression caused by clonidine is common. I have not found any articles describing clonidine as being capable of improving depression. However, it does help ADHD, anxiety, and schizophrenia. As you indicate, clonidine might act very differently at micro-doses compared to using traditional therapeutic dosages. I guess it's possible that, whereas clonidine monotherapy causes depression, it might act very differently when used as an adjunct to other agents.
>
> I'm sure someone knows the answers to these propositions. I don't. It would make a good research project.
>
> Interesting: Compare clonidine to yohimbine.
>
>
> - Scott

Guanfacine, similar in action to clonidine, seems effective, without the deadening low-blood pressure clonidine causes. I honestly don't think clonidine has much efficacy in treating depression, but Guanfacine..possibly, by reducing the stressor effect of norepinephrine. However, vegetative types of depression, I don't think, would respond to either.

Yohimbine is an interesting treatment, as it promotes norepinephrine release, but is also an alpha-2-adrenergic blocker. I actually have had some late interest in trying it for sexual dysfunction. (which it is said to treat.) I did try it, from a health food store, about 25-30 years ago, but with little response.

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:jay2112 thread:1121100
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