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Re: Going with Venlafainxe + Bupropion linkadge

Posted by jay2112 on November 22, 2022, at 21:24:36

In reply to Re: Going with Venlafainxe + Bupropion SLS, posted by linkadge on November 22, 2022, at 15:02:08

> >What kind of impairments? Are they exactly the >same regardless the antidepressant you take?
>
> Basically, I always feel that I am on drugs. It feels like something is controlling my thinking and that I am being blocked off from myself.
>
> For example, I don't get this on ritalin, but I do on bupropion. Even bupropion feels like its compartmentalizing my brain. It's like it is setting up these mental walls and I am only able to live within a certain portion of my brain.
>
> My thoughts are automatically made positive. I am not able to 'see' or analyze a problem properly because it's like the circuitry involved in thinking about anything negative is being blocked off.
>
> I tolerate lithium because it doesn't do this. I can still think deeply about an issue it's just that the intensity of the emotional reaction to a particular thought is lessened. Antidepressants don't reduce the intensity of the negative thoughts, they just prevent me from feeling them at all.
>
> Linkadge
>

I think that, shall we say, 'numbness' is the norepinephrine down-regulation. In my studies in addiction, that is much of what seems to prevent relapse. In case studies, people describe very much of what you are feeling and thinking. It could also be dopamine down-regulation. I have found this feeling, in particular, with the SNRI's, and NDRI's, myself. It's most certainly *NOT* a feeling of 'relief', and that is why there is so much relapse.

Linkadge, there is that new a.d. out that combines bupropion and dextromethorphan. I *have* tried extended release dextromethorphan and low dose Cymbalta, with some quite robust results. Have you thought of combining the Wellbutrin with the dex?

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:jay2112 thread:1121058
URL: http://www.dr-bob.org/babble/20220917/msgs/1121111.html