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Re: Going with Venlafainxe + Bupropion SLS

Posted by undopaminergic on November 22, 2022, at 12:25:37

In reply to Re: Going with Venlafainxe + Bupropion undopaminergic, posted by SLS on November 20, 2022, at 10:51:52

> > >
> > > Like SSRI's, glutamatergic drugs often start out as agonists, then down-regulate and antagonize. Low dose lithium = pro-glutamatergic...high dose down-regulates. Perhaps a higher dose of Memantine would down-regulate, and depress?
> > >
> > > I dunno...just a guess.
> > >
> > > Jay
> >
> >
> > Well, I don't think so, because I took a massive overdose (several grams) of memantine. I recall very little of what happened afterwards, except that I was lying catatonic on the floor performing repeated purposeless movements,
> Do you think that what you experienced was a sort of stereotypy?
> - Scott

I think that is possible, but I'd have to know more about how memantine affects others, especially at higher doses, which may be very hard because it is usually not used clinically at doses higher than 20 mg/day.

I do know, however, that stimulants can produce stereotypy. Given that the manic effects of memantine resemble a stimulant response (dopaminergic-like), it's not unlikely it can do the same.





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