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Re: Going with Venlafainxe + Bupropion jay2112

Posted by undopaminergic on November 20, 2022, at 7:47:56

In reply to Re: Going with Venlafainxe + Bupropion undopaminergic, posted by jay2112 on November 19, 2022, at 14:38:39

> Like SSRI's, glutamatergic drugs often start out as agonists, then down-regulate and antagonize. Low dose lithium = pro-glutamatergic...high dose down-regulates. Perhaps a higher dose of Memantine would down-regulate, and depress?
> I dunno...just a guess.
> Jay

Well, I don't think so, because I took a massive overdose (several grams) of memantine. I recall very little of what happened afterwards, except that I was lying catatonic on the floor performing repeated purposeless movements, and I couldn't muster any will to stop, it just felt pointless. Judging from what I was told by others about what happened, I was more manic than depressed. After I started to remember again, I was still manic, trying to smash the window of my room at the hospital. Then I got gradually more depressed, probably because the memantine was finally wearing off.

So, it appears that memantine can "depress" certain functions, such as memory, but not cause depression, except possibly a mixed state of both depressive and manic symptoms. They did tell me I tried to hang myself in the shower hose.





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