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Re: Going with Venlafainxe + Bupropion

Posted by undopaminergic on November 18, 2022, at 9:47:48

In reply to Re: Going with Venlafainxe + Bupropion linkadge, posted by SLS on November 18, 2022, at 6:39:28

> -----------------------------------------------------
> 1. Low dosages of lithium: Improves depression only.
> 2. Low levels of glutamate are associated with depression.
> -----------------------------------------------------
> 1. High dosages of lithium: Used traditionally for bi1. polar disorder. High dosages are necessary as an acute treatment for an ongoing episode of a mania or for its prophylaxis.
> 2. High levels of glutamate are associated with mania.
> ------------------------------------------------------

The evidence seems to be conflicting. Ketamine, a NMDA-glutamatergic antagonist, improves depression. Memantine, another NMDA-glutamatergic antagonist, can induce mania.

There must be an explanation of course. Perhaps antagonising the NMDA-subtype receptors triggers an increase in glutamatergic tone at other receptor subtypes.





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