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Re: More taychcardia on atomoxetine than Ritalin

Posted by linkadge on November 11, 2022, at 14:09:25

In reply to Re: More taychcardia on atomoxetine than Ritalin linkadge, posted by SLS on November 11, 2022, at 9:54:01

I wanted this medication to help me. Perhaps if it only worked centrally, then I would be able to tolerate it. On pubmed, it is touted as God's gift to ADHD sufferers. It allegedly solves ADHD and accompanying anxiety / depression. I found some of the studies questionable, as they were sponsored by Lilly. The problem is that on patient review sites, it generally only averages a 5 out of 10.

I found atomoxetine to be significantly less tolerable than either wellbutrin or nortriptyline. Interestingly, the antidepressant effect of wellbutrin is (generally) thought to be due to its norepinephrine reuptake inhibition. Yet, even at 300-450mg you are only getting 20-30% occupancy of the norepinephrine transporter. On atomoxetine, 50mg will inhibit 60-80% of the transporter. Yet, despite many trials, atomoxetine has not been found to improve depression. I could not find a single trial that said it worked as monotherapy in depression. The best it could do is augment an SSRI in terms of cognition and energy.

Linkadge



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