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Re: Clorgyline is a imidazoline agonist

Posted by linkadge on October 2, 2022, at 15:51:26

In reply to Re: Clorgyline is a imidazoline agonist linkadge, posted by SLS on October 2, 2022, at 13:03:05

I am going to see a psychiatrist later this month and may ask about an MAOI. I wouldn't mind trying moclobemide, but (as you mention) there have been some issues of efficacy.

I watched a video by Dr. Gillman (the Australian psychiatrist who is a proponent of MAOIS) on Moclobemide. He mentioned the fact that moclobemide seemed to plateau in its ability to inhibit MAO-A. According to some of the studies he was associated with, moclobemide could be displaced from MAO-A by serotonin itself. This, of course, would limit the degree to which it could inhibit MAO-A.

Still, I do know some people who do well on it (especially in combination with lithium). There is a biological mechanism that would support MAO-A as a target in bipolar depression. Apparently, mood stabilizers work to regulate PER2 (which controls circadian rhythm). But, by regulating PER2, there is an upregulation of MAO-A. I hypothesize that MAO-A might become overly active in the depressive phase via PER2.

To be honest, the only benefit I am getting right now is from rhodiola. According to my calculations (translating from animal data) 500mg of rhodiola could inhibit ~30% of MAO-A. I seem to get a noticeable benefit from about 1000mg. I also take amur corktree bark (which is purportedly one of the most potent herbal MAO-B inhibitors). It helps energy. Of course, I'd like to connect with a doctor that is willing try try more than reuptake inhibitors.

https://pubmed.ncbi.nlm.nih.gov/18439826/


Linkadge


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poster:linkadge thread:1120765
URL: http://www.dr-bob.org/babble/20220917/msgs/1120844.html