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Re: Clorgyline is a imidazoline agonist linkadge

Posted by SLS on October 2, 2022, at 13:03:05

In reply to Re: Clorgyline is a imidazoline agonist, posted by linkadge on September 30, 2022, at 17:11:44

> Clorgyline is a potent sigma agonist and an extremely potent imidazoline receptor agonist.
>
> https://en.wikipedia.org/wiki/Clorgiline
>
> "It has been found to bind with high affinity to the sigma 1 receptor (Ki = 3.2 nM)[3][5] and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM).[6]"

I didn't know clorgyline had those additional effects. The neuroscientists of the past didn't have the technology being used today to have determined these things. It makes you want to throw your hands in the air. So much data, so little understanding.

Moclobemide has a stunning antidepressant effect during the first two weeks of treatment. It is what is called a RIMA - a reversible inhibitor of MAO-A. In the long-term, however, it is usually a dead-end. People get well, but don't stay well. My guess is that this is related to its reversibility. It would be interesting to know if moclobemide has some of the same additional properties you cited for clorgyline


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1120765
URL: http://www.dr-bob.org/babble/20220917/msgs/1120837.html