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Re: Clorgyline is a MAOI specific for MAO-A. linkadge

Posted by SLS on October 1, 2022, at 20:15:34

In reply to Re: Clorgyline is a MAOI specific for MAO-A. undopaminergic, posted by linkadge on September 29, 2022, at 16:14:46

> To add to the conversation:
>
> New research suggests that MAO-B doesn't break down dopamine as previously thought (at least not to any appreciable extent). However, as mentioned, it does metabolize PEA and it seems to be involved in the formation of GABA. Inhibiting MAO-B reduces the synthesis of GABA which may have motor improving effects. Also, alpha-synuclein clumping is reduced by inhibiting MAO-B and this may produce some of the therapeutic effects in Parkinsons.
>
> A recent study showed that MAO-B was elevated in the prefrontal cortex of depressed patients. Hence, some degree of MAO-B inhibition may be therapeutic in depression (even if it doesn't produce an immediate mood boost). There is also some evidence that COVID may increase MAO-B levels which may contribute to some of the brain fog / loss of energy in long COVID.
>
> Linkadge
>

I found this earlier today:

"MAO-A and MAO-B, with different substrate specificities4. In particular, epinephrine, norepinephrine, melatonin, and serotonin are mainly metabolized by MAO-A, whereas phenylethylamine and benzylamine are mainly degraded by MAO-B."

https://www.nature.com/articles/s12276-021-00646-3


- Scott


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I dream of things that never were and ask why not.

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poster:SLS thread:1120765
URL: http://www.dr-bob.org/babble/20220917/msgs/1120831.html