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Re: Clorgyline is a MAOI specific for MAO-A. SLS

Posted by undopaminergic on September 30, 2022, at 6:28:50

In reply to Re: Clorgyline is a MAOI specific for MAO-A., posted by SLS on September 29, 2022, at 17:48:52

> As far as the necessity to block both MAO subtypes to treat depression, I haven't come across anything that would lead me to believe that an antidepressant response requires that MAO-B be inhibited. In fact, selegiline and clorgyline demonstrate the reverse. I like to mention clorgyline because it is specific for MAO-A. It doesn't affect MAO-B at all. So, for a bunch of treatment resistant cases of depression, the NIH provided clorgyline for people who responded to nothing else. Many of these patients went home happy for the first time. As the doctors at NIH liked to say, "Clorgyline is our ace-in-the-hole."

But why is clorgyline more effective than nonselective MAOIs? Does it have other mechanisms of action in addition to MAO-A inhibition, or is inhibiting MAO-B a negative thing when treating depression?

Why did you stop using it?





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