Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Clorgyline is a MAOI specific for MAO-A. undopaminergic

Posted by linkadge on September 29, 2022, at 16:14:46

In reply to Re: Clorgyline is a MAOI specific for MAO-A. SLS, posted by undopaminergic on September 29, 2022, at 6:13:35

To add to the conversation:

New research suggests that MAO-B doesn't break down dopamine as previously thought (at least not to any appreciable extent). However, as mentioned, it does metabolize PEA and it seems to be involved in the formation of GABA. Inhibiting MAO-B reduces the synthesis of GABA which may have motor improving effects. Also, alpha-synuclein clumping is reduced by inhibiting MAO-B and this may produce some of the therapeutic effects in Parkinsons.

A recent study showed that MAO-B was elevated in the prefrontal cortex of depressed patients. Hence, some degree of MAO-B inhibition may be therapeutic in depression (even if it doesn't produce an immediate mood boost). There is also some evidence that COVID may increase MAO-B levels which may contribute to some of the brain fog / loss of energy in long COVID.

Linkadge


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:linkadge thread:1120765
URL: http://www.dr-bob.org/babble/20220917/msgs/1120819.html