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Re: Clorgyline is a MAOI specific for MAO-A. SLS

Posted by undopaminergic on September 29, 2022, at 6:13:35

In reply to Clorgyline is a MAOI specific for MAO-A., posted by SLS on September 28, 2022, at 13:52:49

> However, low dosages of selegiline inhibit MAO-B only, which is sufficient for treating Parkinsons Disease. Parkinsons

In the case of selegiline amphetamine metabolites are also involved to an extent. This does not apply to rasagiline.

> is a movement disorder caused by the deterioration of dopamine neuron terminal buttons.

I'm pretty sure the whole cells are affected. They go through apoptosis.

> MAO-A - Norepinephrine and Serotonin
> MAO-B - Norepinephrine and Dopamine

MAO-A metabolises dopamine, and is indeed more involved in that process than MAO-B. I don't think MAO-B breaks down norepinephrine; its preferred substrate seems to be phenylethylamine (PEA).





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