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Re: remission ))

Posted by SLS on September 20, 2022, at 7:16:29

In reply to Re: remission )) Roslynn, posted by Jay2112 on September 19, 2022, at 20:17:12

Hi, Jay.

> > >Amphetamine with carbamazepine has worked unbelievably for me, when I was at my absolute worse. I just thought since Ritalin worked for you, this combo might work.
> > >
> > > Jay
> > >
> > Jay, is your diagnosis unipolar or bipolar 1 or 2?
> >
> > Thank you,
> > Roslynn
> >
> >
> It's Bipolar 2, but my pdoc says it works for any bipolar. Reason being is he is not sure of to put me in bipolar 1 or 2. He thinks it may be a combination, because he has seen this in many other patients. I'd say if Ritalin works for you, try it with carbamazepine. I was 3 weeks in the hospital and it rocketed me out of suicidal depression, with much less hypomania than without carbamazepine.
> Best,
> Jay

Do you think oxcarbazepine (Trileptal) would make for a substitute for carbamazepine (Tegretol)?

The two drugs are chemically related. Oxcarbazepine seems to be as potent as carbamazepine in the majority of studies comparing their efficacies in seizure disorders However, oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of granulocyte white blood cells). Although carbamazepine has this as a possible adverse reaction, it is a rather rare occurrence. Still, periodic blood tests are necessary to assay the number of granulocytes. Agranulocytosis can be fatal.

There is another advantage to oxcarbazepine. It doesn't cause the same sort of sedation and foggy-brain that many people experience with carbamazepine. Not everyone experiences this side-effect, of course. The one caution when taking oxcarbazepine is that it sometimes produces hyponatremia (low blood sodium). This can also be monitored with blood tests at the beginning of treatment. Symptoms of hyponatremia include headache, general malaise, gait disturbance, and somnolence. Often, there are no symptoms at all. I was surprised to learn that as many as 25% of people taking oxcarbazepine develop some degree of hyponatremia. It should be noted that carbamazepine can cause hyponatremia, too, but with a substantially lower frequency.

I felt an enormous difference between the two drugs with respect to sedation and brain-fog. If anything, I found oxcarbazepine to be somewhat stimulating.

There are reasons why someone would want to choose one drug over the other.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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