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Re: neuroleptic dosage, long term

Posted by undopaminergic on September 14, 2022, at 8:29:22

In reply to Re: neuroleptic dosage, long term Christ_empowered, posted by Jay2112 on September 14, 2022, at 3:59:57

> Hi C_e:
>
> I have been on ap's for just over 20 years. I started on ad's about 30 years ago. Now, when I first started the ap's, I thought I would eventually get td, and I do have some very, very mild tremors once in awhile, but not as much as when I was on a very high dose of Prozac. The SRI's do act, sort of, as in a similar method as ap's, suppressing dopamine.
>
> I thought, with the combo of Prozac, Risperdal, and occasional Nozinan (an older ap, similar, but IMHO, way, way less harsher, than the effects of Seroquel) that I would get td, and the Thorazine 'shuffle' at my age. But, as long as I keep a steady, but low dose of my current ad, Effexor, I tolerate the Risperdal and Nozinan very well.
>
>

Parkinsonism, such as tremor, is an acute (and dose-dependent) effect of antipsychotics. Tardive dyskinesia is a problem that develops much later, and consists of dyskinesias, involuntary movements, especially of the facial muscles and tongue.

Second-generation antipsychotics are regarded as less liable to produce TD, but some authors suggest that it is a matter of dose, and that older antipsychotics have been overdosed in comparison to newer ones. More specifically, older off-patent antipsychotics are deliberately overdosed in clinical trials in order to make the new drug look better in comparison.

-undopaminergic


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