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Re: Hepatitis C drugs may help PTSD SLS

Posted by Jay2112 on August 24, 2022, at 22:36:25

In reply to Re: Hepatitis C drugs may help PTSD Jay2112, posted by SLS on August 24, 2022, at 21:08:10

> > For some, Prazosin is ineffective. (Myself included) It did nothing for my nightmares, and made me feel like total sh*t during the day. Clonidine, and one of it's off-shoots I can't recall the name of, combined with propranolol, has been a saviour to me.Perfect combo. I have a very high hart-rate, and these work well to keep me smooth throughout the day. I was diagnosed with PTSD about 7 years ago. I lost a child and partner/wife in a car accident about 24 years ago, but it took that long for me to get decent services and help.
> > This combo extinguishes nightmares, as well as intrusive thoughts/flashbacks and severe anxiety in the daytime.
> >
> > Jay
> >
>
>
> Reports like yours are invaluable, Jay.
>
>
> Clonidine makes sense. It is a presynaptic NE alpha-2 agonist. It probably dampens the fight-or-flight response. However, clonidine is frequently depressogenic, even with people who never had a depressive episode before.
>
> Of the two drugs, which one helps with the nightmares?
>
>
> - Scott

Hey Scott,

Well, c'mon, this is not a peeing match..lol. The clonidine has been my goto for many years. And, one of the largest components of PTSD is all angles of anxiety. That clonidine has some sedative properties has been cited in the literature as an advantage. My PTSD, as I explained, is incredibly complex, with periods of deep, sharp, angular injury, from nightmares, to flashbacks, sweats in -40 weather, like a constant, horrific bombardment of imminent death. I'd walk into a WalMart, hear a child crying, and I would run, rip into my car and into my basement...black...just black, to dark out ANY kind of sound or stimulation.

I tried Prazosin, numerous times, and it completely worsened my symptoms. I found great relief with clonidine, and slightly less with guanfacine. Absolutely NO drug will work for everyone. This piece explains it, for me, anyhow. I am GLAD you found something that works for you.

https://www.mdedge.com/psychiatry/article/104676/ptsd/think-beyond-prazosin-when-treating-nightmares-ptsd

Best

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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URL: http://www.dr-bob.org/babble/20220530/msgs/1120482.html