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Re: Desipramine (Norpramin) best TCA for ADHD?

Posted by undopaminergic on August 12, 2022, at 12:13:46

In reply to Re: Desipramine (Norpramin) best TCA for ADHD?, posted by linkadge on August 12, 2022, at 11:30:13

> Desipramine is probably the best studied TCA for ADHD. That being said, it's got a crappy cardiovascular side effect profile, not to mention being one of the genotoxic TCAs. I wouldn't use it. Why not just use atomoxetine?
> Linkadge

Well, if we're speaking of myself specifically, in my opinion atomoxetine (and reboxetine) have all the side effects of methylphenidate and none of the desirable effects.

To be fair, during my trial of atomoxetine, I set a new record in a DOS computer game I used to play, so maybe it does have some beneficial effect that you just don't notice subjectively.

I tried reboxetine too, and as I've mentioned before, it permanently worsened my depersonalisation/derealisation, in particular numbing my emotions. It was welcome at the time, but in retrospect, I wonder if I hadn't been better off never trying it.

I've also tried ephedrine, and I found it better than atomoxetine and reboxetine, in that it helped slightly with my apathy. However, more generally speaking, it has all the side effects of (dextro-,meth-)amphetamine with little of the benefits.

So why desipramine? That is the question. Is it any better than eg. atomoxetine or nortriptyline?





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