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Re: combining nardil and parnate ) SLS rose45

Posted by SLS on April 5, 2022, at 8:39:01

In reply to Re: combining nardil and parnate ) SLS, posted by rose45 on April 4, 2022, at 17:42:26

> > Hi, Rose.
> >
> > > >
> > > > I don't think I ever asked you how you were feeling.
> > > >
> > > > Don't worry, I won't start now...
> > > >
> > > > Silliness aside, are you hanging in there?
> > > >
> > > >
> > > > - Scott
> >
> > > Im hanging in there but in a very bad way. The NHS want to add lithium. From what I gather from your posts, lithium is not an essential part of your recovery ?
> >
> > .
> >
> > No!
> >
> > Lithium *is* essential for me!
> >
> > However, lithium produces an antidepressant effect for me *only* at 300 mg/day. Once I increase the dosage to 450 mg/day, I begin to deteriorate. It's amazing. I found some literature that suggests an explanation for this. Lithium demonstrates a bimodal effect on both glutamate neurotransmission and clinical response.
> >
> > > Do you think it can kick-start the tcp which is no longer working ? Lamotrigine did kick start it many months ago, but then stopped working and has now completely destroyed my memory and Im finding it very hard to come off it. In fact, Im finding it impossible to come off tcp, or lamotrigine or olanzapine. Just dont know what to do.
> >
> >
> > I have responded best to Parnate when it was combined with either desipramine or nortriptyline.
> >
> > If you have never tried Nardil, I strongly encourage you to do so. It is much better for anxiety than is Parnate. For me, Nardil makes me feel much "brighter" than Parnate. Nardil is also "pro-social". I did not find Parnate capable of doing this, even when it produced a remission of depression.
> >
> >
> > - Scott
> >
> >
> > I thought you said that you take lithium now mainly to stave off Alzheimers.... maybe i misunderstood.
> Nardil was the first med I was ever put on, and it lasted 22 years before it stopped working. I then went on to parnate which I preferred. It suited me very well and had less side effects than nardil. But it stopped working after I reduced it, and now I am unable to come off it, even though it is no longer totally working. The pain is too great. Same is true for lamotrigine.


First of all, why do you want to stop taking Parnate? You know that you are most likely a "lifer", right?. The next time you find something that works, don't rock the boat.

How much Parnate were you taking when it worked best? How would you describe the amount of improvement it produced?

As best as I can estimate from my knowledge of the real-life clinical effective dosage range for Parnate is 40-80 mg/day. A special "high dosage" Parnate begins at 120 mg/day.

I have taken 120 mg/day of Parnate in combination with 300 mg/day of desipramine and some Ritalin. Thyroxine (T4) was added at some point. That is, of course, very aggressive.

One strategy for "recapturing" the antidepressant response when you relapse on Nardil is to discontinue it for three months, and then restart it. One of my doctors had a patient who he had to switch back and forth between Nardil and Parnate.

With lamotrigine (Lamictal), not going up to a minimum of 200 mg is usually optimally effective. Lamotrigine is not an all-or-nothing drug. At 200 mg/day, I glean a partial, although significant response. At 300 mg/day, I experience full remission AND the side-effect of memory impairment disappears, and my memory actually improves as the depression is reduced.

In my estimation, the effective dosage range of lamotrigine to treat bipolar depression is 200-300 mg/day.

You never know.

What are your plans at this point?

- Scott

> Re.lithium, do you do the blood tests regularly... or did you just take 300 mg from the start, without the blood tests?
> Lithium doesnt really help with anxiety does it?

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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