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Re: Combining Prozac and Paxil.... SLS

Posted by Jay2112 on April 3, 2022, at 20:46:46

In reply to Re: Combining Prozac and Paxil.... Jay2112, posted by SLS on April 3, 2022, at 19:42:52

> > > People don't do this. Why? Spinning off the 2 MAOIs at once thread...but....
> >
> > Well, it is actually showing up in the research.
> >
> > This is with youth, but just type in combine ssri pubmed in google, and you will find a whole span.
> >
> > My take, from actually combining Paxil and Prozac, was that is was a point. Paxil has a mellowing anticholinergic action (not as strong, but similar to Elavil (Amitriptyline). Prozac also works on norepinephrine, and GABA. So...with a small dose of Paxil (5mg) and a regular dose of Prozac (20mg), I was able to get a bit more of a calming effect. But, the caveat, is that for some reason (maybe because of Paxil's stronger effect on serotonin) I developed some severe akathisia...inner restlessness. BUT, this was 15 or so years ago, and my dose of Prozac may have been much higher and/or the Paxil dose was higher.
> > It also could have been serotonin syndrome, so you do have to be careful. But, this is not unconventional territory.
> >
> > Best,
> > Jay
> >
> I think the title of the paper you cited is confusing. What the paper is about is combining one SSRI with cognitive-behavioral therapy. I may have missed something, though.
> - Scott

Oppps...sorry. I had bookmarked a few studies with SRI/SRI combos, but now when I need them, I can't find Yes, the study I referenced was a CBT/SRI study.

But, my personal, subjective experience is only n=1, but I swear, I came across a few studies talking about both SRI/SRI and SNRI/SRI combos. One in particular, citalopram and venlafaxine, eased me right out of a horrid mixed episode.


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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